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A scalable synthesis of the (S)-4-(tert-butyl)-2-(pyridin-2-yl)-4,5-dihydrooxazole ((S)-t-BuPyOx) ligand

An efficient method for the synthesis of the (S)-4-(tert-butyl)-2-(pyridin-2-yl)-4,5-dihydrooxazole ((S)-t-BuPyOx) ligand has been developed. Inconsistent yields and tedious purification in known routes to (S)-t-BuPyOx suggested the need for an efficient, dependable, and scalable synthetic route. Fu...

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Detalhes bibliográficos
Main Authors: Shimizu, Hideki, Holder, Jeffrey C, Stoltz, Brian M
Formato: Artigo
Idioma:Inglês
Publicado em: Beilstein-Institut 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778391/
https://ncbi.nlm.nih.gov/pubmed/24062823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.9.187
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