Interferon-β gene-modified human bone marrow mesenchymal stem cells attenuate hepatocellular carcinoma through inhibiting AKT/FOXO3a pathway

OBJECTIVE: This study aims to investigate the using of bone marrow mesenchymal stem cells (BMSCs) genetically engineered to produce interferon-β (IFN-β) as a gene delivery system to treat hepatocellular carcinoma (HCC) in vitro and in vivo. METHODS: To measure the effects on tumour cell growth in vi...

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Detalhes bibliográficos
Main Authors: Xie, C, Xie, D-Y, Lin, B-L, Zhang, G-L, Wang, P-P, Peng, L, Gao, Z-L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778282/
https://ncbi.nlm.nih.gov/pubmed/23887606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.422
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