Combining Next-Generation Sequencing and Immune Assays: A Novel Method for Identification of Antigen-Specific T Cells

In this study, we combined a novel sequencing method, which can identify individual clonotypes based on their unique T cell receptor (TCR) rearrangement, with existing immune assays to characterize antigen-specific T cell responses. We validated this approach using three types of assays routinely us...

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Bibliographic Details
Main Authors: Klinger, Mark, Kong, Katherine, Moorhead, Martin, Weng, Li, Zheng, Jianbiao, Faham, Malek
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778005/
https://ncbi.nlm.nih.gov/pubmed/24069285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074231
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