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Mycobacterium tuberculosis mutation rate estimates from different lineages predict substantial differences in the emergence of drug resistant tuberculosis

A critical question in tuberculosis control is why some strains of Mycobacterium tuberculosis are preferentially associated with multiple drug resistances. We demonstrate that M. tuberculosis strains from Lineage 2 (East Asian lineage and Beijing sublineage) acquire drug resistances in vitro more ra...

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Detalhes bibliográficos
Main Authors: Ford, Christopher B., Shah, Rupal R., Maeda, Midori Kato, Gagneux, Sebastien, Murray, Megan B., Cohen, Ted, Johnston, James C., Gardy, Jennifer, Lipsitch, Marc, Fortune, Sarah M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777616/
https://ncbi.nlm.nih.gov/pubmed/23749189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2656
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