Point Mutations in the Transmembrane Region of the Clic1 Ion Channel Selectively Modify Its Biophysical Properties

Chloride intracellular Channel 1 (CLIC1) is a metamorphic protein that changes from a soluble cytoplasmic protein into a transmembrane protein. Once inserted into membranes, CLIC1 multimerises and is able to form chloride selective ion channels. Whilst CLIC1 behaves as an ion channel both in cells a...

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Main Authors: Averaimo, Stefania, Abeti, Rosella, Savalli, Nicoletta, Brown, Louise J., Curmi, Paul M. G., Breit, Samuel N., Mazzanti, Michele
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776819/
https://ncbi.nlm.nih.gov/pubmed/24058583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074523
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