Enhanced Cardiac Function in Gravin Mutant Mice Involves Alterations in the β-Adrenergic Receptor Signaling Cascade

Gravin, an A-kinase anchoring protein, targets protein kinase A (PKA), protein kinase C (PKC), calcineurin and other signaling molecules to the beta2-adrenergic receptor (β(2)-AR). Gravin mediates desensitization/resensitization of the receptor by facilitating its phosphorylation by PKA and PKC. The...

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Detalhes bibliográficos
Main Authors: Guillory, Ashley N., Yin, Xing, Wijaya, Cori S., Diaz Diaz, Andrea C., Rababa’h, Abeer, Singh, Sonal, Atrooz, Fatin, Sadayappan, Sakthivel, McConnell, Bradley K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776749/
https://ncbi.nlm.nih.gov/pubmed/24058627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074784
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