Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis

Interleukin-23 is a key cytokine involved in the generation of Th17 effector cells. Clinical efficacy of an anti-p40 mAb blocking both IL-12 and IL-23 and disease association with single nucleotide polymorphisms in the IL23R gene raise the question of a functional role of IL-23 in psoriasis. In this...

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Autores principales: Tonel, Giulia, Conrad, Curdin, Laggner, Ute, Di Meglio, Paola, Grys, Katarzyna, McClanahan, Terrill K., Blumenschein, Wendy M., Qin, Jian-Zhong, Xin, Hong, Oldham, Elizabeth, Kastelein, Robert, Nickoloff, Brian J., Nestle, Frank O.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776381/
https://ncbi.nlm.nih.gov/pubmed/20956338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001538
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