aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation

The atypical protein kinase C (aPKC) is a key regulator of polarity and cell fate in lower organisms. However, whether mammalian aPKCs control stem cells and fate in vivo is not known. Here we show that loss of aPKCλ in a self-renewing epithelium, the epidermis, disturbed tissue homeostasis, differe...

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Autors principals: Niessen, Michaela T., Scott, Jeanie, Zielinski, Julia G., Vorhagen, Susanne, Sotiropoulou, Panagiota A., Blanpain, Cédric, Leitges, Michael, Niessen, Carien M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2013
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776350/
https://ncbi.nlm.nih.gov/pubmed/24019538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201307001
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