aPKCλ controls epidermal homeostasis and stem cell fate through regulation of division orientation

The atypical protein kinase C (aPKC) is a key regulator of polarity and cell fate in lower organisms. However, whether mammalian aPKCs control stem cells and fate in vivo is not known. Here we show that loss of aPKCλ in a self-renewing epithelium, the epidermis, disturbed tissue homeostasis, differe...

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Detalhes bibliográficos
Main Authors: Niessen, Michaela T., Scott, Jeanie, Zielinski, Julia G., Vorhagen, Susanne, Sotiropoulou, Panagiota A., Blanpain, Cédric, Leitges, Michael, Niessen, Carien M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776350/
https://ncbi.nlm.nih.gov/pubmed/24019538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201307001
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