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Polyplex-Induced Cytosolic Nuclease Activation leads to Differential Transgene Expression

Cytosolic nucleases have been proposed to play an important role in limiting the effectiveness of polyplex-based gene delivery agents. In order to explore the effect of cell membrane disruption on nuclease activation, nuclease activity upon polyplex uptake and localization, and nuclease activity upo...

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Bibliografiske detaljer
Main Authors: Rattan, Rahul, Vaidyanathan, Sriram, Wu, Gordon S.-H., Shakya, Anisha, Orr, Bradford G., Banaszak Holl, Mark M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776314/
https://ncbi.nlm.nih.gov/pubmed/23834286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp400103f
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