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Polyplex-Induced Cytosolic Nuclease Activation leads to Differential Transgene Expression
Cytosolic nucleases have been proposed to play an important role in limiting the effectiveness of polyplex-based gene delivery agents. In order to explore the effect of cell membrane disruption on nuclease activation, nuclease activity upon polyplex uptake and localization, and nuclease activity upo...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3776314/ https://ncbi.nlm.nih.gov/pubmed/23834286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp400103f |
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