Possible Role of Intestinal Fatty Acid Oxidation in the Eating-Inhibitory Effect of the PPAR-α Agonist Wy-14643 in High-Fat Diet Fed Rats

PPAR-α plays a key role in lipid metabolism; it enhances fatty acid oxidation (FAO) and ketogenesis. Pharmacological PPAR-α activation improves insulin sensitivity and reduces food intake, but its mechanisms of action remain unknown. We here report that intraperitoneal (IP) administration of the PPA...

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Autores principales: Karimian Azari, Elnaz, Leitner, Claudia, Jaggi, Thomas, Langhans, Wolfgang, Mansouri, Abdelhak
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775792/
https://ncbi.nlm.nih.gov/pubmed/24069361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074869
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