Molecular genetic characterization of p53 mutated oropharyngeal squamous cell carcinoma cells transformed with human papillomavirus E6 and E7 oncogenes

Patients with HPV-positive oropharyngeal cancer show better tumor response to radiation or chemotherapy than patients with HPV-negative cancer. HPV oncoprotein E6 binds and degrades a typically wild-type p53 protein product. However, HPV16 infection and p53 mutation infrequently coexist in a subset...

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Main Authors: OH, JI-EUN, KIM, JEONG-OH, SHIN, JUNG-YOUNG, ZHANG, XIANG-HUA, WON, HYE-SUNG, CHUN, SANG-HOON, JUNG, CHAN-KWON, PARK, WON-SANG, NAM, SUK-WOO, EUN, JUNG-WOO, KANG, JIN-HYOUNG
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775581/
https://ncbi.nlm.nih.gov/pubmed/23708675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2013.1953
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