SOCS3 Expression Correlates with Severity of Inflammation, Expression of Proinflammatory Cytokines, and Activation of STAT3 and p38 MAPK in LPS-Induced Inflammation In Vivo

SOCS3 is an inducible endogenous negative regulator of JAK/STAT pathway, which is relevant in inflammatory conditions. We used a model of LPS-induced periodontal disease in rats to correlate SOCS3 expression with the inflammatory status. In vitro we used a murine macrophage cell line to assess the p...

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Bibliographic Details
Main Authors: Chaves de Souza, João Antônio, Nogueira, Andressa Vilas Boas, Chaves de Souza, Pedro Paulo, Kim, Yeon Jung, Silva Lobo, Caroline, Pimentel Lopes de Oliveira, Guilherme José, Cirelli, Joni Augusto, Garlet, Gustavo Pompermaier, Rossa, Carlos
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775441/
https://ncbi.nlm.nih.gov/pubmed/24078776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/650812
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