BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63(+) cytotrophoblast stem cell state

The placenta is a transient organ that is necessary for proper fetal development. Its main functional component is the trophoblast, which is derived from extra-embryonic ectoderm. Little is known about early trophoblast differentiation in the human embryo, owing to lack of a proper in vitro model sy...

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Bibliographische Detailangaben
Hauptverfasser: Li, Yingchun, Moretto-Zita, Matteo, Soncin, Francesca, Wakeland, Anna, Wolfe, Lynlee, Leon-Garcia, Sandra, Pandian, Raj, Pizzo, Donald, Cui, Li, Nazor, Kristopher, Loring, Jeanne F., Crum, Christopher P., Laurent, Louise C., Parast, Mana M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Company of Biologists 2013
Schlagworte:
Stem Cells and Regeneration
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775414/
https://ncbi.nlm.nih.gov/pubmed/24004950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.092155
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