The autoimmune disease-associated SNP rs917997 of IL18RAP controls IFNγ production by PBMC

Type 1 Diabetes (T1D) is an autoimmune disorder characterized by aberrant T cell responses. Innate immune activation defects may facilitate a T helper 1 (Th1) phenotype. The cytokine IL-18 synergizes with IL-12 to induce IFNγ production and Th1 differentiation. The IL-18R subunit (IL18RAP) SNP rs917...

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Main Authors: Myhr, Courtney B., Hulme, Maigan A., Wasserfall, Clive H., Hong, Peter J., Lakshmi, Priya Saikumar, Schatz, Desmond A., Haller, Michael J., Brusko, Todd M., Atkinson, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775347/
https://ncbi.nlm.nih.gov/pubmed/23891168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2013.06.001
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