RXRα overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRα-null fetuses

Retinoid X receptor α–null (RXRα-null) mutants exhibit hypoplasia of their ventricular myocardium and die at the fetal stage. In the present study, we wished to determine whether transgenic re-expression of RXRα in mutant cardiac myocytes could rescue these defects. Two transgenic mouse lines specif...

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書誌詳細

出版年:	J Clin Invest
主要な著者:	Subbarayan, Vemparala, Mark, Manuel, Messadeq, Nadia, Rustin, Pierre, Chambon, Pierre, Kastner, Philippe
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Clinical Investigation 2000
主題:	Article
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC377445/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10675365/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI8150
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