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Differential immune responses to α-gal epitopes on xenografts and allografts: implications for accommodation in xenotransplantation
Xenograft recipients produce large amounts of high-affinity anti-Gal IgG in response to Galα1-3Galβ1- 4GlcNAc-R (α-gal) epitopes on the graft. In contrast, ABO-mismatched allograft recipients undergo “accommodation,” a state of very weak immune response to ABO antigens. These differences in anti-car...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC377438/ https://ncbi.nlm.nih.gov/pubmed/10675356 |
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