Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH(2)-terminal (sites 2 + 2a) phosphorylation

Type 2 diabetes is characterized by reduced muscle glycogen synthesis. The key enzyme in this process, glycogen synthase (GS), is activated via proximal insulin signaling, but the exact molecular events remain unknown. Previously, we demonstrated that phosphorylation of Thr(308) on Akt (p-Akt-Thr(30...

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Main Authors: Friedrichsen, Martin, Birk, Jesper B., Richter, Erik A., Ribel-Madsen, Rasmus, Pehmøller, Christian, Hansen, Bo Falck, Beck-Nielsen, Henning, Hirshman, Michael F., Goodyear, Laurie J., Vaag, Allan, Poulsen, Pernille, Wojtaszewski, Jørgen F. P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774094/
https://ncbi.nlm.nih.gov/pubmed/23321478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00494.2012
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