Anti-inflammatory and immunomodulatory properties of α1-antitrypsin without inhibition of elastase

The rationale of α1-antitrypsin (AAT) augmentation therapy to treat progressive emphysema in AAT-deficient patients is based on inhibition of neutrophil elastase; however, the benefit of this treatment remains unclear. Here we show that clinical grade AAT (with elastase inhibitory activity) and a re...

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Autors principals: Jonigk, Danny, Al-Omari, Mariam, Maegel, Lavinia, Müller, Meike, Izykowski, Nicole, Hong, Jaewoo, Hong, Kwangwon, Kim, Soo-Hyun, Dorsch, Martina, Mahadeva, Ravi, Laenger, Florian, Kreipe, Hans, Braun, Armin, Shahaf, Galit, Lewis, Eli C., Welte, Tobias, Dinarello, Charles A., Janciauskiene, Sabina
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773761/
https://ncbi.nlm.nih.gov/pubmed/23975926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309648110
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