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Observation of Two Modes of Inhibition of Human Microsomal Prostaglandin E Synthase 1 by the Cyclopentenone, 15-Deoxy-Δ(12, 14)-Prostaglandin J(2)
Microsomal prostaglandin E synthase 1 (MPGES1) is an enzyme that produces the pro-inflammatory molecule PGE(2). Effective inhibitors of MPGES1 are of considerable pharmacological interest for the selective control of pain, fever and inflammation. The isoprostane, 15-deoxy-Δ(12–14)-PGJ(2) (15d-PGJ(2)...
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| Hoofdauteurs: | , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3773687/ https://ncbi.nlm.nih.gov/pubmed/22356188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2019332 |
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