Observation of Two Modes of Inhibition of Human Microsomal Prostaglandin E Synthase 1 by the Cyclopentenone, 15-Deoxy-Δ(12, 14)-Prostaglandin J(2)

Microsomal prostaglandin E synthase 1 (MPGES1) is an enzyme that produces the pro-inflammatory molecule PGE(2). Effective inhibitors of MPGES1 are of considerable pharmacological interest for the selective control of pain, fever and inflammation. The isoprostane, 15-deoxy-Δ(12–14)-PGJ(2) (15d-PGJ(2)...

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Detalhes bibliográficos
Main Authors: Prage, Edward B., Morgenstern, Ralf, Jakobsson, Per-Johan, Stec, Donald F., Voehler, Markus W., Armstrong, Richard N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773687/
https://ncbi.nlm.nih.gov/pubmed/22356188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi2019332
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