Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis

Small-cell lung cancer (SCLC) easily recurs with a multidrug resistant phenotype. However, standard therapeutic strategies for relapsed SCLC remain unestablished. We found that human epidermal growth factor receptor 2 (HER2) is not only expressed in pretreated human SCLC specimens, but is also upreg...

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Hlavní autoři: Minami, Toshiyuki, Kijima, Takashi, Kohmo, Satoshi, Arase, Hisashi, Otani, Yasushi, Nagatomo, Izumi, Takahashi, Ryo, Miyake, Kotaro, Higashiguchi, Masayoshi, Morimura, Osamu, Ihara, Shoichi, Tsujino, Kazuyuki, Hirata, Haruhiko, Inoue, Koji, Takeda, Yoshito, Kida, Hiroshi, Tachibana, Isao, Kumanogoh, Atsushi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773623/
https://ncbi.nlm.nih.gov/pubmed/24036898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02669
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