Effect of Temporally Patterned TNF-α Delivery on In Vitro Osteogenic Differentiation of Mesenchymal Stem Cells Cultured on Biodegradable Polymer Scaffolds

Recent insight into the critical role of pro-inflammatory cytokines, particularly tumor necrosis factor-α (TNF-α), in bone regeneration has heralded a new direction in the design of bone tissue engineering constructs. Previous studies have demonstrated that continuous delivery of 50 ng/ml TNF-α to m...

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Hauptverfasser: Mountziaris, Paschalia M., Lehman, E. Dennis, Mountziaris, Ioannis, Sing, David C., Kasper, F. Kurtis, Mikos, Antonios G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773264/
https://ncbi.nlm.nih.gov/pubmed/23746285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/09205063.2013.803455
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