STE20/SPS1-Related Proline/Alanine-Rich Kinase Is Involved in Plasticity of GABA Signaling Function in a Mouse Model of Acquired Epilepsy

The intracellular concentration of chloride ([Cl(-)](i)) determines the strength and polarity of GABA neurotransmission. STE20/SPS1-related proline/alanine-rich kinase (SPAK) is known as an indirect regulator of [Cl(-)](i) for its activation of Na-K-2 Cl(-)co-transporters (NKCC) and inhibition of K-...

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Detalhes bibliográficos
Main Authors: Yang, Libai, Cai, Xiaodong, Zhou, Jueqian, Chen, Shuda, Chen, Yishu, Chen, Ziyi, Wang, Qian, Fang, Ziyan, Zhou, Liemin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772887/
https://ncbi.nlm.nih.gov/pubmed/24058604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074614
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