Reactivation of Estrogen Receptor α by Vorinostat Sensitizes Mesenchymal-Like Triple-Negative Breast Cancer to Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor

OBJECTIVE: Aminoflavone (AF) acts as a ligand of the aryl hydrocarbon receptor (AhR). Expression of estrogen receptor α (ERα) and AhR-mediated transcriptional induction of CYP1A1 can sensitize breast cancer cells to AF. The objective of this study was to investigate the combined antitumor effect of...

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Hauptverfasser: Stark, Karri, Burger, Angelika, Wu, Jianmei, Shelton, Phillip, Polin, Lisa, Li, Jing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772827/
https://ncbi.nlm.nih.gov/pubmed/24058584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074525
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