Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP

The 70kD heat shock proteins (Hsp70s) are ubiquitous molecular chaperones essential for cellular protein folding and proteostasis. Each Hsp70 has two functional domains: a nucleotide-binding domain (NBD) that binds and hydrolyzes ATP, and a substrate-binding domain (SBD) that binds extended polypept...

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Autori principali: Qi, Ruifeng, Sarbeng, Evans Boateng, Liu, Qun, Le, Katherine Quynh, Xu, Xinping, Xu, Hongya, Yang, Jiao, Wong, Jennifer Li, Vorvis, Christina, Hendrickson, Wayne A., Zhou, Lei, Liu, Qinglian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772632/
https://ncbi.nlm.nih.gov/pubmed/23708608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2583
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