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Modulation of KCNQ1 alternative splicing regulates cardiac I(Ks) and action potential repolarization
BACKGROUND: I(Ks) channels, made of the pore-forming KCNQ1 and auxiliary KCNE1 subunits, play a key role in determining action potential duration (APD) in cardiac myocytes. The consequences of drug-induced KCNQ1 splice alteration remain unknown. OBJECTIVE: We study the modulation of KCNQ1 alternativ...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3771516/ https://ncbi.nlm.nih.gov/pubmed/23608591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2013.04.014 |
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