SAMHD1 restricts HIV-1 by reducing the intracellular pool of deoxynucleotide triphosphates

SAMHD1 restricts human immunodeficiency virus-1 (HIV-1) infection of dendritic and other myeloid cells at an early stage in the replication cycle. SIVsm/HIV-2 lineage viruses counteract SAMHD1-mediated restriction by encoding Vpx, a virion-packaged accessory protein that targets SAMHD1 for degradati...

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Autori principali: Lahouassa, Hichem, Daddacha, Waaqo, Hofmann, Henning, Ayinde, Diana, Logue, Eric C., Dragin, Loïc, Bloch, Nicolin, Maudet, Claire, Bertrand, Matthieu, Gramberg, Thomas, Pancino, Gianfranco, Priet, Stéphane, Canard, Bruno, Laguette, Nadine, Benkirane, Monsef, Transy, Catherine, Landau, Nathaniel R., Kim, Baek, Margottin-Goguet, Florence
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771401/
https://ncbi.nlm.nih.gov/pubmed/22327569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2236
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