SEPSIS INDUCES EARLY ALTERATIONS IN INNATE IMMUNITY THAT IMPACT MORTALITY TO SECONDARY INFECTION

Sepsis, the systemic inflammatory response to microbial infection, induces changes in both innate and adaptive immunity that presumably lead to increased susceptibility to secondary infections, multi-organ failure and death. Using a model of murine polymicrobial sepsis whose severity approximates hu...

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Main Authors: Delano, Matthew J., Thayer, Terri, Gabrilovich, Sonia, Kelly-Scumpia, Kindra M., Winfield, Robert D., Scumpia, Philip O., Cuenca, Alex G., Warner, Elizabeth, Wallet, Shannon M., Wallet, Mark A., O’Malley, Kerri A., Ramphal, Reuben, Clare-Salzer, Michael, Efron, Philip A., Mathews, Clayton E., Moldawer, Lyle L.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771366/
https://ncbi.nlm.nih.gov/pubmed/21106855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002104
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