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A Dose-Escalation Study of Recombinant Human Interleukin-18 in Combination with Rituximab in Patients with Non-Hodgkin's Lymphoma

Interleukin-18 (IL-18) is an immunostimulatory cytokine with antitumor activity in preclinical models. Rituximab is a CD20 monoclonal antibody with activity against human B cell lymphomas. A phase I study of recombinant human (rh) IL-18 given with rituximab was performed in patients with CD20+ lymph...

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Hlavní autoři: Robertson, Michael J., Kline, Justin, Struemper, Herbert, Koch, Kevin M., Bauman, John W., Gardner, Olivia S., Murray, Sharon C., Germaschewski, Fiona, Weisenbach, Jill, Jonak, Zdenka, Toso, John F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770482/
https://ncbi.nlm.nih.gov/pubmed/23799412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e31829d7e2e
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