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Mitochondrial DNA Instability in Cells Lacking Aconitase Correlates with Iron Citrate Toxicity
Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate. aco1Δ results in mitochondrial DNA (mtDNA) instability. It has been proposed that Aco1 binds to mtDNA and mediates its mainte...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Hindawi Publishing Corporation
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3770056/ https://ncbi.nlm.nih.gov/pubmed/24066190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/493536 |
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