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Redesign of substrate specificity and identification of aminoglycoside binding residues of Eis from Mycobacterium tuberculosis
The upsurge of drug-resistant tuberculosis (TB) is an emerging global problem. Increased expression of the enhanced intracellular survival (Eis) protein is responsible for clinical resistance to aminoglycoside (AG) antibiotics in Mycobacterium tuberculosis. Eis from M. tuberculosis (Eis_Mtb) and fro...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3769965/ https://ncbi.nlm.nih.gov/pubmed/23837529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4002985 |
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