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The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial design
Many anticancer agents damage DNA and activate cell cycle checkpoints that permit time for the cells to repair their DNA and recover. These checkpoints have undergone intense investigation as potential therapeutic targets and Chk1 inhibitors have emerged as promising novel therapeutic agents. Chk1 w...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Science Inc
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3769664/ https://ncbi.nlm.nih.gov/pubmed/23593991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12139 |
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