Proteomic Signatures of Acquired Letrozole Resistance in Breast Cancer: Suppressed Estrogen Signaling and Increased Cell Motility and Invasiveness

Aromatase inhibitors, such as letrozole, have become the first-line treatment for postmenopausal women with estrogen-dependent breast cancer. However, acquired resistance remains a major clinical obstacle. Previous studies demonstrated constitutive activation of the MAPK signaling, overexpression of...

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Główni autorzy: Tilghman, Syreeta L., Townley, Ian, Zhong, Qiu, Carriere, Patrick P., Zou, Jin, Llopis, Shawn D., Preyan, Lynez C., Williams, Christopher C., Skripnikova, Elena, Bratton, Melyssa R., Zhang, Qiang, Wang, Guangdi
Format: Artigo
Język:Inglês
Wydane: The American Society for Biochemistry and Molecular Biology 2013
Hasła przedmiotowe:
Research
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769322/
https://ncbi.nlm.nih.gov/pubmed/23704778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.023861
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