Reducing FLI1 Levels in the MRL/lpr Lupus Mouse Model Impacts T Cell Function by Modulating Glycosphingolipid Metabolism

Systemic Lupus erythematosus (SLE) is an autoimmune disease caused, in part, by abnormalities in cells of the immune system including B and T cells. Genetically reducing globally the expression of the ETS transcription factor FLI1 by 50% in two lupus mouse models significantly improves disease measu...

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Detalhes bibliográficos
Main Authors: Richard, Erin Morris, Thiyagarajan, Thirumagal, Bunni, Marlene A., Basher, Fahmin, Roddy, Patrick O., Siskind, Leah J., Nietert, Paul J., Nowling, Tamara K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769295/
https://ncbi.nlm.nih.gov/pubmed/24040398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075175
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