Vector Sequences Are Not Detected in Tumor Tissue from Research Subjects with Ornithine Transcarbamylase Deficiency Who Previously Received Adenovirus Gene Transfer

A 66-year-old woman heterozygous for a mutation in the ornithine transcarbamylase gene (Otc) participated in a phase I gene therapy trial for OTC deficiency. She received an adenovirus (Ad) vector expressing the functional OTC gene by intraportal perfusion. Fourteen years later she developed and sub...

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Detalhes bibliográficos
Main Authors: Zhong, Li, Li, Shaoyong, Li, Mengxin, Xie, Jun, Zhang, Yu, Lee, Brendan, Batshaw, Mark L., Wilson, James M., Gao, Guangping
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3768231/
https://ncbi.nlm.nih.gov/pubmed/24010702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.118
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