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Neural Mechanisms of Age-Related Slowing: The ΔCBF/ΔCMRO(2) Ratio Mediates Age-Differences in BOLD Signal and Human Performance

The precise mechanisms that give rise to the blood-oxygen-level-dependent (BOLD) activation differences that accompany age-related cognitive slowing remain fundamentally unknown. We sought to isolate the origin of age-related BOLD changes by comparing blood-flow and oxygen-metabolic constituents of...

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Detalhes bibliográficos
Main Authors: Hutchison, Joanna L., Lu, Hanzhang, Rypma, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767961/
https://ncbi.nlm.nih.gov/pubmed/22879349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhs233
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