Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells

OBJECTIVE: Metaplastic lineages in the oxyntic mucosa of the stomach are critical preneoplastic precursors of gastric cancer. Recent studies have demonstrated that Spasmolytic polypeptide-expressing metaplasia (SPEM) in the mouse oxyntic mucosa arises from transdifferentiation of mature gastric chie...

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Bibliographic Details
Main Authors: Nam, Ki Taek, O’Neal, Ryan L., Coffey, Robert J., Finke, Paul E., Barker, Nick, Goldenring, James R.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767919/
https://ncbi.nlm.nih.gov/pubmed/22198711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-301193
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