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In vivo activation of the p53 tumor suppressor pathway by an engineered cyclotide
The overexpression of Hdm2 and HdmX is a common mechanism used by many tumor cells to inactive the p53 tumor suppressor pathway promoting cell survival. Targeting Hdm2 and HdmX has emerged as a validated therapeutic strategy for treating cancers with wild-type p53. Small linear peptides mimicking th...
Tallennettuna:
| Päätekijät: | , , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3767463/ https://ncbi.nlm.nih.gov/pubmed/23848581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja405108p |
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