Polygenic Heritability Estimates in Pharmacogenetics: Focus on Asthma and Related Phenotypes

While accurate measures of heritability are needed to understand the pharmacogenetic basis of drug treatment response, these are generally not available, since it is unfeasible to give medications to individuals for which treatment is not indicated. Using a polygenic linear mixed modeling approach,...

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Main Authors: McGeachie, Michael J, Stahl, Eli A, Himes, Blanca E, Pendergrass, Sarah A., Lima, John J., Irvin, Charles G., Peters, Stephen P., Ritchie, Marylyn D, Plenge, Robert M, Tantisira, Kelan G
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767309/
https://ncbi.nlm.nih.gov/pubmed/23532052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e3283607acf
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