Matrix Stiffness Corresponding to Strictured Bowel Induces a Fibrogenic Response in Human Colonic Fibroblasts

BACKGROUND: Crohn’s disease is characterized by repeated cycles of inflammation and mucosal healing which ultimately progress to intestinal fibrosis. This inexorable progression towards fibrosis suggests that fibrosis becomes inflammation-independent and auto-propagative. We hypothesized that matrix...

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Autors principals: Johnson, Laura A., Rodansky, Eva S., Sauder, Kay L., Horowitz, Jeffrey C., Mih, Justin D., Tschumperlin, Daniel J., Higgins, Peter D.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766259/
https://ncbi.nlm.nih.gov/pubmed/23502354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0b013e3182813297
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