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A selective antagonist of histamine H(4) receptors prevents antigen-induced airway inflammation and bronchoconstriction in guinea pigs: involvement of lipocortin-1

BACKGROUND AND PURPOSE: Among the pathogenic mechanisms of asthma, a role for oxidative/nitrosative stress has been well documented. Recent evidence suggests that histamine H(4) receptors play a modulatory role in allergic inflammation. Here we report the effects of compound JNJ 7777120 (JNJ), a sel...

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Bibliografiske detaljer
Main Authors: Somma, T, Cinci, L, Formicola, G, Pini, A, Thurmond, R, Ennis, M, Bani, D, Masini, E
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764861/
https://ncbi.nlm.nih.gov/pubmed/23734568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12264
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