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Knockdown of Diacylglycerol Kinase Delta Inhibits Adipocyte Differentiation and Alters Lipid Synthesis

OBJECTIVE: Decreased expression of diacylglycerol kinase delta (DGKδ) has been linked to insulin resistance in humans and mice and is abundantly expressed in adipose tissue. We therefore examined its role in adipogenesis. DESIGN AND METHODS: We generated 3T3-L1 preadipocytes in which DGKδ expression...

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Detalhes bibliográficos
Main Authors: LOWE, Christopher E., ZHANG, Qifeng, DENNIS, Rowena J., AUBRY, Evelyne A., O’RAHILLY, Stephen, WAKELAM, Michael J.O., ROCHFORD, Justin J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763967/
https://ncbi.nlm.nih.gov/pubmed/23703849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.20297
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