Pharmacological Properties and Discriminative Stimulus Effects of a Novel and Selective 5-HT(2) Receptor Agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]

AL-38022A is a novel synthetic serotonergic (5-HT) ligand that exhibited high affinity for each of the 5-HT(2) receptor subtypes (K(i) ≤ 2.2 nM), but a significantly lower (>100-fold less) affinity for other 5-HT receptors. In addition, AL-38022A displayed a very low affinity for a broad array of...

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Main Authors: May, Jesse A., Sharif, Najam A., Chen, Hwang-Hsing, Liao, John C., Kelly, Curtis R., Glennon, Richard A., Young, Richard, Li, Jun-Xu, Rice, Kenner C., France, Charles P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763814/
https://ncbi.nlm.nih.gov/pubmed/18718483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2008.07.015
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