Simulations of Biased Agonists in the β(2) Adrenergic Receptor with Accelerated Molecular Dynamics

[Image: see text] The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G protein-signaling pathway a GPCR promotes intracellular signals though β-arrestin, is a novel paradigm in pharmacology. Biochemical and biophysical studies have suggested that a GPCR...

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Huvudupphovsmän: Tikhonova, Irina G., Selvam, Balaji, Ivetac, Anthony, Wereszczynski, Jeff, McCammon, J. Andrew
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2013
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763781/
https://ncbi.nlm.nih.gov/pubmed/23879802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400499n
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