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Simulations of Biased Agonists in the β(2) Adrenergic Receptor with Accelerated Molecular Dynamics
[Image: see text] The biased agonism of the G protein-coupled receptors (GPCRs), where in addition to a traditional G protein-signaling pathway a GPCR promotes intracellular signals though β-arrestin, is a novel paradigm in pharmacology. Biochemical and biophysical studies have suggested that a GPCR...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2013
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3763781/ https://ncbi.nlm.nih.gov/pubmed/23879802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400499n |
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