Susceptibility of Podocytes to Palmitic Acid Is Regulated by Stearoyl-CoA Desaturases 1 and 2

Type 2 diabetes mellitus is characterized by dyslipidemia with elevated free fatty acids (FFAs). Loss of podocytes is a hallmark of diabetic nephropathy, and podocytes are highly susceptible to saturated FFAs but not to protective, monounsaturated FFAs. We report that patients with diabetic nephropa...

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Main Authors: Sieber, Jonas, Weins, Astrid, Kampe, Kapil, Gruber, Stefan, Lindenmeyer, Maja T., Cohen, Clemens D., Orellana, Jana M., Mundel, Peter, Jehle, Andreas W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2013
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763774/
https://ncbi.nlm.nih.gov/pubmed/23867797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.05.023
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