Identification of Fibril-Like Tertiary Contacts in Soluble Monomeric α-Synuclein

Structural conversion of the presynaptic, intrinsically disordered protein α-synuclein into amyloid fibrils underlies neurotoxicity in Parkinson’s disease. The detailed mechanism by which this conversion occurs is largely unknown. Here, we identify a discrete pattern of transient tertiary interactio...

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Bibliographische Detailangaben
Hauptverfasser: Esteban-Martín, Santiago, Silvestre-Ryan, Jordi, Bertoncini, Carlos W., Salvatella, Xavier
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Biophysical Society 2013
Schlagworte:
Proteins and Nucleic Acids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762368/
https://ncbi.nlm.nih.gov/pubmed/24010662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.07.044
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