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A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes

Painful episodes of vaso-occlusion are the leading cause of hospitalizations and emergency department visits in sickle cell disease, and are associated with increased mortality. Low nitric oxide bioavailability contributes to vasculopathy in sickle cell disease. Since arginine is the obligate substr...

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Detalhes bibliográficos
Main Authors: Morris, Claudia R., Kuypers, Frans A., Lavrisha, Lisa, Ansari, Michael, Sweeters, Nancy, Stewart, Melinee, Gildengorin, Ginny, Neumayr, Lynne, Vichinsky, Elliott P.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762093/
https://ncbi.nlm.nih.gov/pubmed/23645695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2013.086637
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