Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis

mTOR integrates signals from nutrients and growth factors to control protein synthesis, cell growth, and survival. Although mTOR has been established as a therapeutic target in hematologic malignancies, its physiological role in regulating hematopoiesis remains unclear. Here we show that conditional...

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Detalhes bibliográficos
Main Authors: Guo, Fukun, Zhang, Shuangmin, Grogg, Matthew, Cancelas, Jose A., Varney, Melinda E., Starczynowski, Daniel T., Du, Wei, Yang, Jun-Qi, Liu, Wei, Thomas, George, Kozma, Sara, Pang, Qishen, Zheng, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3762090/
https://ncbi.nlm.nih.gov/pubmed/23716557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.080424
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