Coupling Unbiased Mutagenesis to High-throughput DNA Sequencing Uncovers Functional Domains in the Ndc80 Kinetochore Protein of Saccharomyces cerevisiae

During mitosis, kinetochores physically link chromosomes to the dynamic ends of spindle microtubules. This linkage depends on the Ndc80 complex, a conserved and essential microtubule-binding component of the kinetochore. As a member of the complex, the Ndc80 protein forms microtubule attachments thr...

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Bibliographic Details
Main Authors: Tien, Jerry F., Fong, Kimberly K., Umbreit, Neil T., Payen, Celia, Zelter, Alex, Asbury, Charles L., Dunham, Maitreya J., Davis, Trisha N.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2013
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3761298/
https://ncbi.nlm.nih.gov/pubmed/23833183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.152728
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